New technical paper titled “Planar Junctionless Field-Effect Transistor for Detecting Biomolecular Interactions” was published from researchers at Max Planck Center for Complex Fluid Dynamics, University of Twente, University of Glasgow, and Luxembourg Institute of Science and Technology (LIST).
“Label-free field-effect transistor-based immunosensors are promising candidates for proteomics and peptidomics-based diagnostics and therapeutics due to their high multiplexing capability, fast response time, and ability to increase the sensor sensitivity due to the short length of peptides. In this work, planar junctionless field-effect transistor sensors (FETs) were fabricated and characterized for pH sensing. The device with SiO2 gate oxide has shown voltage sensitivity of 41.8 ± 1.4, 39.9 ± 1.4, 39.0 ± 1.1, and 37.6 ± 1.0 mV/pH for constant drain currents of 5, 10, 20, and 50 nA, respectively, with a drain to source voltage of 0.05 V. The drift analysis shows a stability over time of −18 nA/h (pH 7.75), −3.5 nA/h (pH 6.84), −0.5 nA/h (pH 4.91), 0.5 nA/h (pH 3.43), corresponding to a pH drift of −0.45, −0.09, −0.01, and 0.01 per h. Theoretical modeling and simulation resulted in a mean value of the surface states of 3.8 × 1015/cm2 with a standard deviation of 3.6 × 1015/cm2. We have experimentally verified the number of surface sites due to APTES, peptide, and protein immobilization, which is in line with the theoretical calculations for FETs to be used for detecting peptide-protein interactions for future applications.”
Find the technical paper here. Published August 2022.
Shukla, R.P.; Bomer, J.G.; Wijnperle, D.; Kumar, N.; Georgiev, V.P.; Singh, A.C.; Krishnamoorthy, S.; Pascual García, C.; Pud, S.; Olthuis, W. Planar Junctionless Field-Effect Transistor for Detecting Biomolecular Interactions. Sensors< 2022, 22, 5783. https://doi.org/10.3390/s22155783.
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